Core 16 - Joseph Graziano

Core 16 - Joseph Graziano

Manganese Health Research Program: Phase 2, Core 16

Research Core Project Number:  
Research Core Project: Water-Borne Manganese Exposure and Motor Function in Young Adults
Core Principal Investigator (CPI): Joseph Graziano, PhDName
AffiliationColumbia University
Mailman School of Public Health
Department of Environmental Health Sciences
Contact details60 Haven Ave, B-1
New York, NY 10032
Phone: 212-305-1678
Key Collaborators:

Gail Wasserman, PhD
Columbia University & NYS Psychiatric Institute 
Department of Psychiatry - Child & Adolescent Psychiatry     
1051 Riverside Drive 
New York NY, 10032     
Phone: 212-543-5296

Xinhua Liu, PhD
Columbia University
Mailman School of Public Health
Department of Biostatistics
722 W. 168th Street, 6th Floor
New York, NY 10032
Phone: 212 342 1262

Project Objectives:

This project seeks to test the hypothesis that total manganese (Mn) exposure from drinking water and diet may be adversely related to motor function in young adults, 18-21 years of age.  The field work took place in Araihazar, Bangladesh, where Mn concentrations in drinking water are variable and often elevated well above the WHO guideline level of 300 ug/L.  The project sought to recruit 100 young men and 100 young women, half of whom were consuming water with < 300 ug/L Mn and half above that.  Motor function was assessed using the Bruininks-Oseretsky -2 test of motor functioning, a well validated instrument.  In addition, a validated dietary survey questionnaire was administered to obtain data on dietary Mn, and a validated questionnaire concerning exercise, a covariate, was administered since exercise influences motor function.  Finally, blood measurements of Mn and various parameters of iron metabolism were also carried out.

Project Status:

Project started:     2008                     
Scheduled completion date:  12/31/08  
Anticipated completion date:  December 2011  

Key Research Accomplishments:

Laboratory measurements of all blood and urine parameters have been completed and are illustrated in Table 3.  As expected, serum iron (Fe) and blood hemoglobin concentrations were lower in women than men.  All of these blood measurements will be considered in our statistical modeling that ultimately examines the relationship between total daily Mn intake and motor function.  Each of four sub-tests of the BOT-2 (fine motor control, body coordination, manual coordination, and strength & agility) will be examined independently, as will the total standardized test scores

Data entry for the BOT-2 and dietary survey have been completed, while the entry of the physical activity questionnaire is nearing completion.  Upon completion of this data entry, our final regression modeling can be carried out to test our hypothesis.

Conclusions and Publications:

No conclusions have yet been reached.  Statistical analyses are about to begin within days, as we are nearing the completion of data entry into a central database.  Our statistician, Dr. Xinhua Liu, is poised to begin work on this once data entry is completed.  We hope to be able to submit an abstract to the annual meeting of the Superfund Research Program by August 15th.

Last updated: August 16, 2011

About cookies on our website

Following a revised EU directive on website cookies, each company based, or doing business, in the EU is required to notify users about the cookies used on their website.

Our site uses cookies to improve your experience of certain areas of the site and to allow the use of specific functionality like social media page sharing. You may delete and block all cookies from this site, but as a result parts of the site may not work as intended.

To find out more about what cookies are, which cookies we use on this website and how to delete and block cookies, please see our Which cookies we use page.

Click on the button below to accept the use of cookies on this website (this will prevent the dialogue box from appearing on future visits)